JUSUNG AN - Projects

The broad research objective is to develop organic and bioinorganic materials to enhance our understanding of life-threatening diseases, including cancer and Alzheimer's disease. To achieve this goal, I am adopting an interdisciplinary approach that integrates organic chemistry, inorganic chemistry, and chemical biology. This approach aims to develop novel chemical compounds with unique physicochemical and biochemical properties, transforming them into highly effective and biocompatible small molecule agents for groundbreaking disease diagnosis and therapy.

Outlined below are two major areas of interest that I have developed in my research journey:

Diagnostic Agents for Alzheimer's Disease

Accurate detection and analysis of amyloid biomarkers at the cellular level within the disease microenvironment are crucial for basic research and preclinical applications in Alzheimer's disease. Developing optimized fluorescent probes with high sensitivity and biocompatibility is essential. By focusing on in vitro kinetic analysis and in vivo imaging, these advancements will shed light on the complexities of Alzheimer's disease.

Selected Articles:
Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid
J. An,† K. Kim,† H. J. Lim, H. Y. Kim, J. Shin, I. Park, I. Cho, H. Y. Kim, S. Kim, C. McLean, K. Y. Choi, Y. Kim,* K. H. Lee,* J. S. Kim*, Nat. Commun., 15, 1004 (2024) Read here

A Fluorescent Probe for Investigating the Role of Biothiols in Signaling Pathways Associated with Cerebral Ischemia‐Reperfusion Injury
Y. Yang,† M. Ma, L. Shen, J. An,† E. Kim, H. Liu, M. Jin, S. Wang, J. Zhang, J. S. Kim,* C. Yin*, Angew. Chem., Int. Ed., 62, e202310408 (2023) Read here

Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes
J. An,† P. Verwilst,† H. Aziz,† J. Shin,† S. Lim, I. Kim, Y. K. Kim, J. S. Kim, Bioact. Mater., 13, 239-248 (2022) Read here

Photosensitizers for Cancer

Photodynamic and photooxygenating agents, which generate reactive oxygen species under light irradiation, serve as powerful tools in cancer therapy. The development of novel photosensitizers is set to enhance photodynamic therapy strategies, leading to improved therapeutic outcomes.

Selected Articles:
Lutetium texaphyrin-celecoxib conjugate as a potential immuno-photodynamic therapy agent
J. An,† K.-P. Lv,† C. V. Chau,† J. H. Lim,† R. Parida, X. Zheng, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee,* D. Luo,* Q. Liu,* J. L. Sessler,* J. S. Kim* , J. Am. Chem. Soc., 146, 19434-19448 (2024) Read here

2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy
Y. Xu,† Y. Wang,† J. An,† A. C. Sedgwick,† M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, Bioact. Mater., 14, 76-85 (2022) Read here

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens
Y. Xu,† Y. Zhang,† J. Li,† J. An,† C. Li, S. Bai, A. Sharma, G. Deng, J. S. Kim,* Y. Sun*, Biomaterials, 259, 120315 (2020) Read here

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